(+)-medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (er) β-mediated osteogenic action. (+)-medicarpin, a pterocarpan, is a type of isoflavonoid isolated
ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. ftorafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome p-450 enzyme.
n-dodecanoyl-l-homoserine lactone is a quorum sensing (qs) signaling molecule, a microbial communication mechanism modulated by acyl homoserine lactone (ahl) molecules impacts biofilm formation in bioreactors.
nicotinamide riboside increases nad[+] levels and activates sirt1 and sirt3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
n-oleoyl glycine, a lipoamino acid, was able to promote 3t3-l1 adipogenesis through the activation of cb1 receptor and the enhancement of insulin-mediated akt signaling pathway.
p-coumaric acid ethyl ester is the ethyl ester of p-coumaric acid. p-coumaric acid is a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis.
penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8.penicillic acid is a polyketide mycotoxin produced by several species of aspergillus and penicillium. penicillic acid exhibits cytotoxicity in rat alveolar macr
phytohemagglutinin is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein bax and activating caspases-3. anti-tumor activity
chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. like the other drugs in this class chlorpromazine´s antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. chlorpr
(r,s)-anatabine is a minor tobacco alkaloid found in the solanaceae family of plants,and can be used as a specific marker for the detection of tobacco use.
ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. ribocil strongly inhibits gfp expression, achieving a 50% effective concentration (ec50: 0.3 μm).
(s,s,s)-ahpc hydrochloride is a vhl amino building block, is a ligand used as a negative control for (s,r,s)-ahpc. it is the vh032-based vhl ligand used in the recruitment of the vhl protein.
shield-1 is a specific, high-affinity and cell-permeant ligand of fk506-binding protein-12 (fkbp), and reverses the instability by binding to mutated fkbp (mtfkbp), allowing conditional expression of mtfkbp-fused proteins. shield-1 can stabilize the entir
panthenol (pantothenol) is the alcohol analog of pantothenic acid (vitamin b5) and is thus a provitamin of b5. in organisms, it is quickly oxidized to pantothenate.
hymecromone is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. it is also used in analytical chemistry techniques for the determination of nitric acid.
sodium butyrate is the sodium salt of butyrate with potential antineoplastic activity. butyrate, a short chain fatty acid, competitively binds to the zinc sites of class i and ii histone deacetylases (hdacs).
ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (nsaid) with anti-inflammatory, analgesic, and antipyretic effects. ibuprofen inhibits the activity of cyclo-oxygenase i and ii, resulting in a decreased formation of precursor
uc-514321 directly targets stat3/5 and represses tet1 expression. uc-514321 has the potential to treat acute myeloid leukemia (aml) both in vitro and in vivo, with low toxicity.